Computational analysis of doublesex isoforms in Anopheles gambiae

Authors

  • Mabel Serrano Instituto Tecnológico de Santo Domingo (INTEC), Santo Domingo, República Dominicana. https://orcid.org/0009-0002-3908-4195
  • Cheryl Marte Instituto Tecnológico de Santo Domingo (INTEC), Santo Domingo, República Dominicana. https://orcid.org/0009-0001-2335-443X
  • Nasla Gomez Instituto Tecnológico de Santo Domingo (INTEC), Santo Domingo, República Dominicana. https://orcid.org/0009-0003-2227-562X
  • Manuel Colomé-Hidalgo Universidad Autónoma de Santo Domingo (UASD) Santo Domingo, República Dominicana. https://orcid.org/0000-0002-4562-6491
  • Edian Franco Instituto Tecnológico de Santo Domingo (INTEC), Santo Domingo, República Dominicana. - Instituto de Innovación en Biotecnología e Industria (IIBI) Santo Domingo, República Dominicana. https://orcid.org/0000-0001-9715-9437
  • Pedro María Alarcón-Elbal Grupo de Investigación de Zoonosis Transmitidas por Vectores (ZOOVEC), Departamento de Producción y Sanidad Animal, Salud Pública Veterinaria y Ciencia y Tecnología de los Alimentos (PASAPTA), Facultad de Veterinaria, Universidad CEU Cardenal Herrera, CEU Universities, Alfara del Patriarca, Valencia, España. https://orcid.org/0000-0001-5319-4257
  • Alejandro Vallejo Degaudenzi Instituto Tecnológico de Santo Domingo (INTEC), Santo Domingo, República Dominicana. 2 Universidad Autónoma de Santo Domingo (UASD) Santo Domingo, República Dominicana. https://orcid.org/0000-0003-2057-2332

DOI:

https://doi.org/10.62430/rtb20262412138

Keywords:

splicing alternativo, determinación sexual, análisis in silico, bioseguridad, malaria, control vectorial

Abstract

The doublesex (dsx) gene is involved in sex determination in Anopheles gambiae sensu stricto and is a potential target for vector control. The objective was to computationally characterize its sex-specific isoforms. Materials and methods: An in silico analysis of RA and RB isoforms was performed using VectorBase data, evaluating gene architecture, CDS length, and predicted protein products. RA and RB showed structural and protein-length differences while preserving the reading frame. RB-derived theoretical variants allowed the effect of terminal modifications to be explored without introducing frameshift changes. The functional diversity of dsx is associated with alternative splicing and supports its relevance as a molecular target for future genetic vector control research.

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Published

2026-06-02

How to Cite

Serrano, M., Marte, C., Gomez, N., Colomé-Hidalgo, M., Franco, E., Alarcón-Elbal , P. M., & Vallejo Degaudenzi, A. (2026). Computational analysis of doublesex isoforms in Anopheles gambiae. The Biologist, 24(1). https://doi.org/10.62430/rtb20262412138