INFECTION BY LEISHMANIA SPP. IN THE HAMSTER MESOCRICETUS AURATUS USING PROMASTIGOTES CULTURED IN VITRO

Authors

  • Jesús Eduardo Rojas-Jaimes Laboratorio de Parasitología-Facultad de Ciencias Biológicas –Universidad Nacional Mayor de San Marcos (UNMSM), Lima, Perú. https://orcid.org/0000-0002-6910-9341
  • José Iannacone Laboratorio de Ecología y Biodiversidad Animal (LEBA). Facultad de Ciencias Naturales y Matemática (FCCNM). Universidad Nacional Federico Villarreal (UNFV). El Agustino, Lima, Perú. 3Facultad de Ciencias Biológicas. Universidad Ricardo Palma (URP). Santiago de Surco, Lima, Perú. https://orcid.org/0000-0003-3699-4732

DOI:

https://doi.org/10.24039/rtb20151321555

Keywords:

infection, immunosuppression, Leishmania, virulence

Abstract

Leishmaniasis is an endemic chronic degenerative disease of the mountains and jungle of Peru causing a social stigma in people who suffer from the wounds it causes. In vivo models make it necessary to study this neglected disease. In the present study immunosuppressed hamsters Mesocricetus auratus were infected with promastigotes of L. infantum, L. brazilensis, L. guyanensis and L. peruviana cultivated in vitro in order to observe the progression of the disease in four months. No disease progression was observed in the time stipulated probably by loss of virulence of the Leishmania sp. promastigotes used in the challenge. The results show that infection and progression of leishmaniasis requires conditions such as virulence and viability and that this is lost due to the passages in vitro cultures.

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Published

2015-12-12

How to Cite

Rojas-Jaimes, J. E., & Iannacone, J. (2015). INFECTION BY LEISHMANIA SPP. IN THE HAMSTER MESOCRICETUS AURATUS USING PROMASTIGOTES CULTURED IN VITRO. The Biologist, 13(2), 367–374. https://doi.org/10.24039/rtb20151321555

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Original Articles