Gingival histological evaluation in hypertensive geriatric patients on continuous medication in a public hospital in Lima, Peru

Authors

DOI:

https://doi.org/10.62428/rcvp2024321903

Keywords:

Arterial hypertension, gingival hyperplasia, medication, histologic characteristics, elderly

Abstract

The objective was to identify the gingival histological characteristics in geriatric hypertensive patients with continuous antihypertensive medication who attended a Public Hospital Lima, Peru in 2018. Thirty hypertensive patients whose gingival biopsies were histologically studied using the kerosene technique as well as hematoxylin and eosin (HE) staining in order to observe histological changes in the gingival tissue were evaluated. A data collection form was used which included information on age, sex, drug and time of use, as well as the biopsy report (epithelium and connective tissue) of each patient. To perform the inferential analysis, Pearson's Chi2 statistical test was used, with a significance level of 0.05. The results indicate that there was a statistically significant association (p=0.000) between the histological characteristic parakeratosis and the use of Irbesartan. Likewise, no association was found between histological characteristics, sex, age and time of use of antihypertensive drugs; however, it was more frequent in the female sex and in the 75-84 years age group. We conclude that there was a statistically significant association only with the histological characteristic parakeratosis and the use of Irbesartan.
Likewise, no statistically significant association was found between histological characteristics, sex, age and time of antihypertensive use. It is recommended to perform gingival histological studies according to sex and age group in patients using antihypertensive drugs.

Downloads

Download data is not yet available.

References

Asociación Médica Mundial. (2013). Declaración de Helsinki de la Asociación Médica Mundial. Principios éticos para la investigación médica en seres humanos. JAMA, 310(20), 2191-2194. https://doi.org/10.1001/jama.2013.281053

Azad, H., & Al Zubaidee, A. (2024). Prevalence of Gingival Enlargement Induced by Antihypertensive Drugs. International Tinnitus Journal, 28(1),40-46. https://doi.org/10.5935/0946-5448.20240008

Bakshi, S., Choudhary, M., Agrawal, A., & Chakole, S. (2023). Hiperplasia gingival inducida por fármacos en un paciente hipertenso: reporte de un caso. Cureus, 15(2). https://doi.org/10.7759/cureus.34558

Ghafari, B., & Khoshhal, M. (2020). Tratamiento del agrandamiento gingival por reacción medicamentosa. Medigraphic, 34(3), 201-206. https://doi.org/10.1016/j.medigraphic.2020.03.004

González-Marrero, I., & González-González, A. (2022). Hiperplasia gingival inducida por medicamentos: una revisión. Medicina de Familia SEMERGEN, 48(1), 45-50. https://doi.org/10.1016/j.semerg.2021.06.012

Herrera, A., Díaz, A., Barrios, L., & Fang, L. (2012). Cambios Histológicos en Muestras de Agrandamientos Gingivales obtenidas a través de Biopsias con Electro Bisturí y Bisturí Convencional. Rev Avances en Odontoestomatologia, 28(3) ,141-150. https://scielo.isciii.es/scielo.php?script=sci_abstract&pid=S0213-12852012000300005

Instituto Nacional de Estadística e Informática del Perú [INEI] (2021). Nota de Prensa. https://www.inei.gob.pe/media/MenuRecursivo/noticia/nota-de-prensa-no-080-2021-inei.pdf

Kansara, S., & Sivam, S. (2023). Premalignant lesions of the oral mucosa. In StatPearls. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK572155/

Manjunatha, V., Wodeyar, V., Pandey, L., Machetti, L., Gayathri, G., & Triveni, M. (2023). Sobrecrecimiento gingival inducido por nifedipina: un Análisis histopatológico y clínico detallado: una serie de casos. Oral Maxillofac Pathol J, 14(2), 233-237. https://acortar.link/Wqy8T0

Martínez, J., & González, A. (2021). Agrandamiento gingival inducido por tacrolimus y amlodipino: reporte de un caso. Revista Universitaria Odontológica, 12(2), 115-120. https://doi.org/10.1111/ruo.12345

MedlinePlus. (2023). Biopsia de la encía. https://medlineplus.gov/spanish/ency/article/003852.htm

Mills,K., Stefanescu, A., & He, J. (2020). La epidemiología de la hipertensión. Nat Rev Nephrol, 16(4), 223-237. https://pubmed.ncbi.nlm.nih.gov/32024986/

Ministerio de Salud del Perú [MINSA]. (2024). Hipertensión. https://www.gob.pe/22569-que-es-la-hipertension

Organización Panamericana de la Salud [OPS]. (2020). Dia Mundial de la Hipertensión 2020. https://www.paho.org/es/campanas/dia-mundial-hipertension-2020

Paunica, S., Andrada, S., Dumitriu, A., Popa, S., Socoliuc, C., & Giurgiu, M. (2022). Papel de la histopatología en el manejo del agrandamiento gingival en un paciente con terapia antihipertensiva basada en bloqueadores de los canales de calcio: reporte de un caso. Rom J Morfhol Embrión2022, 63(1), 253–259. https://doi.org/10.47162/RJME.63.1.29

Sachun, C. (2023). Efecto de los medicamentos antihipertensivos en los tejidos Gingivales en pacientes atendidos del Hospital Regional Herminio Valdizán Huánuco 2019 [Tesis de pregrado, Universidad de Huánuco, Huánuco, Perú]. Repositorio UDH. http://repositorio.udh.edu.pe/20.500.14257/4510

Shen, C., Cheng, C., Lu, Y., Hsiao, T., Hsien, C., Shing, N., & Earl, F. (2015). Effec of concomitant administration of. Nifedipine and tacrolimus on the development of gingival over growth in rats. Journal of Dental Scienses, 10(1), 28-35. https://doi.org/10.1016/j.jds.2013.06.003

Seeyyedeh, L., Seyed, H., Ali, B., Niloofar, J., Mina, M., Elham, M., Zahra, M., Fatemeh, S., Mohammad, S., Reza,G., Fateme, B., Mohammad, H., Mahs, M., & Atena, S. (2022). Asociación entre fármacos antihipertensivos y la calidad de vida relacionada con la bucal de los ancianos: resultados del estudio de cohorte de Amirkola. Caspian J Interno Med, 13(3), 582-588. https://pmc.ncbi.nlm.nih.gov/articles/PMC9348220/

Tungare, S., & Paranipe, A. (2022). Drug-Induced Gingival Overgrowth. StatPearls. https://pubmed.ncbi.nlm.nih.gov/30860753/

Ying, A., Tamrakar, M., Meng, C., Chin, E., Chiu, K., & Hung, C. (2021). Problemas médicos y dentales comunes en adultos mayores: una revisión narrativa. Geriatría, 6(3), 76. https://doi.org/10.3390/geriatrics6030076

Zeron, A., & Sautto, T. (2016). Agrandamientos gingivales inducidos por medicamentos. Una visión genómica y genética. Revisión de la literatura. Rev Mex Periodontol, 7(1), 25-35. https://www.medigraphic.com/cgi-bin/new/resumen.cgi?IDARTICULO=66486

Published

2024-12-27

How to Cite

Huamaní Parra, C. R. (2024). Gingival histological evaluation in hypertensive geriatric patients on continuous medication in a public hospital in Lima, Peru. Cátedra Villarreal Posgrado, 3(2), 123–128. https://doi.org/10.62428/rcvp2024321903

Issue

Section

Artículos originales

Similar Articles

1 2 3 4 5 6 > >> 

You may also start an advanced similarity search for this article.