Bases moleculares del Sueño
DOI:
https://doi.org/10.24039/rtb20232111521Palabras clave:
Genes, Dopaminérgico , Molécula , Trastorno , SueñoResumen
El sueño es vital para todos los mamíferos incluyendo al ser humano, su distorsión implica diferentes riesgos para la salud y patologías como depresión, enfermedades cardiovasculares y en el extremo puede llevar a la muerte. En ese sentido es de importancia encontrar las bases moleculares del sueño entre ellos los genes y sus proteínas que ejecutan un rol clave en la homeostasis del ser vivo. Se recopiló información utilizando las bases de datos PubMed/Scopus en ingles con 10 años de anterioridad utilizando el protocolo PICO para determinar las palabras P=Genes, I=Base molecular, C=No aplica, O= Sueño. Se determinaron artículos originales en dos grandes grupos entre estos estan los “Genes Reloj” y otros “Genes y Proteínas” relacionados al sueño. Entre los genes reloj de importancia identificados están los vinculados a la dopamina (DRD 2) y el (DAT 1) y otros genes como el pdm3 que participa en la génesis de la inervación del sistema dopaminérgico y los genes ANXA3 y 17GAM, en la que se ha demostrado que una sobreexpresión de estos se relaciona a la privación del sueño. Entender las bases moleculares del sueño y sus vacíos aun por estudiar son clave para futuros estudios como identificar dianas y drogas para tratar los trastornos del sueño.
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Remuneración: La cesión de los derechos patrimoniales de autor que mediante este contrato se hace será a título gratuito.
Condiciones y legitimidad de los derechos: El AUTOR-CEDENTE garantiza que es propietario integral de los derechos de explotación de la(s) obra(s) y en consecuencia garantiza que puede contratar y transferir los derechos aquí cedidos sin ningún tipo de limitación por no tener ningún tipo de gravamen, limitación o disposición. En todo caso, responderá por cualquier reclamo que en materia de derecho de autor se pueda presentar, exonerando de cualquier responsabilidad al CESIONARIO.
Licencia de acceso abierto: El AUTOR-CEDENTE autoriza que manuscrito publicado en la Revista Científica The Biologist (Lima) (versión Impresa ISSN 1816-0719, versión en línea ISSN 1994-9073) permanece disponible para su consulta pública en el sitio web http://revistas.unfv.edu.pe/index.php/rtb/index y en los diferentes sistemas de indexación y bases de datos en las que la revista tiene visibilidad, bajo la licencia Creative Commons, en la modalidad Reconocimiento-No comercial- Sin Trabajos derivados –aprobada en Perú, y por lo tanto son de acceso abierto. De ahí que los autores dan, sin derecho a retribución económica, a la Escuela Profesional de Biología, Facultad de Ciencias Naturales y Matemática de la Universidad Nacional Federico Villarreal (EPB - FCCNM - UNFV), los derechos de autor para la edición y reproducción a través de diferentes medios de difusión.
